ameliorated – Communicable Diseases Research

Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds

양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS-CoV-2

Article

Published on 2022-11-082022-11-15
Journal: EMBO Molecular Medicine
[Category] SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 Administered administration ameliorated Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody betacoronaviruses bind catalytic activity catalytically active Clinical use COVID-19 decoy demonstrated effective entry receptor High dose Host increased survival Infection Inflammation inoculated intravenous intravenously K18-hACE2 mice Loss Lung injury mechanism neutralization potency neutralize omicron Omicron variant persist PROTECT receptor receptor. reduced sACE2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants shown substrate target the SARS-CoV-2 therapeutic efficacy therapeutic potential Treatment virus
[DOI] 10.15252/emmm.202216109 PMC 바로가기

Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and Functionality

Article

Published on 2022-09-042022-11-15
Journal: International Journal of Molecular Sciences
[Category] 진단,

[키워드] activity aggregation ameliorated anti-inflammatory activity Autoimmune disease carboxymethyllysine (CML) cascade caused cholesterol CIGB-258 (Jusvinza) CML co-injection coronavirus disease COVID-19 cytokine Cytokine storm death death rate decrease developmental Efficacy Embryo enhancement exhibited faster ferrous ion Final HDL Heat shock high-density high-density lipoproteins (HDL) highest Hsp60 hyperinflammation infiltration Inflammation Inflammatory inflammatory cells infliximab inhibit injected injection kDa Ligand lipoprotein lowest mechanism neutrophil Pain paralysis Particle peptide plasma protective effect Protein resulting stability Stress Survivability systemic inflammation tissue treated Triglyceride was tested zebrafish zebrafish.
[DOI] 10.3390/ijms231710130 PMC 바로가기

Effect of Ultra-Micronized Palmitoylethanolamide and Luteolin on Olfaction and Memory in Patients with Long COVID: Results of a Longitudinal Study

Randomized Controlled Trial

Published on 2022-08-172022-10-05
Journal: Cells
[Category] 임상,

[키워드] absence affected age ameliorated Anosmia average baseline Biomarkers Brain brain fog Combination COVID COVID-19 disorders Effect group Hyposmia interval investigated Long long-haul COVID syndrome longitudinal lutein Luteolin measure mechanisms memory men Mental mental clouding Neuroinflammation Olfaction olfactory olfactory dysfunction olfactory threshold olfactory training outcomes palmitoylethanolamide parosmia Patient patients PEA-LUT Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Prevalence qualitative smell disorders Quantitative Randomized receive recruited reduction in regimen remaining group Result SARS-COV-2 infection self-report measure severity smell disorders. subjects subsequent therapy thresholds Treatment were assessed women
[DOI] 10.3390/cells11162552 PMC 바로가기 [Article Type] Randomized Controlled Trial

SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1

SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다

Article

Published on 2022-08-012022-09-11
Journal: Metabolism: clinical and experimental
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19
[DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article

PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils

Article

Published on 2022-07-222022-11-15
Journal: JCI Insight
[Category] 진단,

Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation

Research

Published on 2022-06-222022-10-05
Journal: Acta pharmacologica Sinica
[Category] 바이오마커,

[키워드] activated Activation addition administration ameliorated Analysis Anti-inflammatory Apoptosis Caco-2 cells Cell cell proliferation Colitis Colon colonic comparable degranulation down-regulated downstream gene downstream signaling pathways epithelial expression in vitro in vivo inactivation Inflammation inhibited inhibiting injection intestinal intestinal inflammation investigated involved MAPK mechanism neutrophil neutrophil degranulation neutrophil recruitment NF-κB prevented pro-inflammatory cytokine promoted Protein Proteins proteomic recruitment regulated restored S100A9 signaling pathway significantly suppressed therapeutic therapeutic effect TLR4
[DOI] 10.1038/s41401-022-00933-3 [Article Type] Research

Sensory Ataxic Guillain-Barré Syndrome with Dysgeusia after mRNA COVID-19 Vaccination

mRNA COVID-19 예방접종 후 미각장애를 동반한 감각운동실조 길랑-바레 증후군

Case Reports

Published on 2022-06-012022-09-11
Journal: Internal medicine (Tokyo, Japan)
[Category] COVID19(2023년), SARS, 변종, 치료기술,

Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration

Research

Published on 2022-05-132022-10-05
Journal: Signal Transduction and Targeted Therapy
[Category] 바이오마커,

An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

Research

Published on 2022-04-272022-10-05
Journal: Nature Microbiology
[Category] COVID19(2023년), SARS, 변종, 치료제,